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☆ More people need transplants than there are organ donors. Pigs might offer a solution
▼ + stars: | 2024-01-30 | by ( Jen Christensen | ) edition.cnn.com time to read: +23 min

The need for more transplant organs is immense and growing. Researchers have transplanted genetically modified pig kidneys and hearts into people who were brain-dead to test whether they work in humans. Although Larry Faucette was too sick for a human heart transplant, University of Maryland doctors said he seemed physically strong enough for a genetically modified pig heart. It was more than a decade after the first heart transplant but long before such procedures became relatively routine. “We learned that the pig heart is an adequate substitute for a human heart.

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Lawrence Faucette was dying from heart failure and ineligible for a traditional heart transplant when doctors at the University of Maryland School of Medicine offered the highly experimental surgery. In the first glimpse of Faucette provided since the Sept. 20 transplant, hospital video shows physical therapist Chris Wells urging him to push through a pedaling exercise to regain his strength. The Maryland team last year performed the world’s first transplant of a heart from a genetically altered pig into another dying man. David Bennett survived just two months before that heart failed, for reasons that aren’t completely clear although signs of a pig virus later were found inside the organ. In Friday’s hospital video, Faucette’s doctors said the pig heart has shown no sign of rejection.

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☆ Doctor's transplanted a genetically-engineered pig heart into a human, again, and now the saved patient has reached a major milestone
▼ + stars: | 2023-10-20 | by ( Lauran Neergaard | Associated Press | ) www.businessinsider.com time to read: +3 min

The pig heart transplant patient lived to celebrate the one-month anniversary of his surgery. The first pig heart transplant patient died two months after surgery due to heart failure. The first pig heart transplant patient, David Bennett, died two months after surgery. In Friday's hospital video, Faucette's doctors said the pig heart has shown no sign of rejection. Tom Jemski/University of Maryland School of Medicine via APMany scientists hope xenotransplants one day could compensate for the huge shortage of human organ donations.

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Two days later, the man was cracking jokes and able to sit in a chair, Maryland doctors said Friday. “You know, I just keep shaking my head – how am I talking to someone who has a pig heart?” Dr. Bartley Griffith, who performed the transplant, told The Associated Press. “It’s just an amazing feeling to see this pig heart work in a human,” said Dr. Muhammad Mohiuddin, the Maryland team’s xenotransplantation expert. That FDA allowed this second case “suggests that the agency is not ready to permit a pig heart clinical trial to start,” Mashke added. The pig heart, provided by Blacksburg, Virginia-based Revivicor, has 10 genetic modifications – knocking out some pig genes and adding some human ones to make it more acceptable to the human immune system.

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